CD220 Monoclonal / PE-Vio770 / REA260
Product Details
| Description | Clone REA260 recognizes the CD220 antigen, a type I transmembrane receptor tyrosine kinase, which is also known as insulin receptor (IR). CD220 is predominantly expressed in major target tissues of insulin metabolic effects like liver, adipose tissue, and skeletal muscle, but is also expressed in the peripheral nerve, kidney, fibroblasts, monocytes, granulocytes, erythrocytes, and skin. It is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Upon binding of insulin, CD220 forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine kinase activity of the receptor. CD220 plays a key role in the regulation of glucose homeostasis, cell growth, differentiation, and apoptosis- functional processes that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. | Additional information: Clone REA260 displays negligible binding to Fc receptors. | | |
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| Conjugate | PE-Vio770 | |
| Clone | REA260 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About CD220
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
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Validation References
| PMID 2986534 | |
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| PMID 17347799 | |
| PMID 20230616 | |
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