CD151 Monoclonal / Biotin / REA265
Product Details
| Description | Clone REA265 recognizes the CD151 antigen, a 29 kDa cell surface glycoprotein, which is also known as platelet-endothelial tetraspan antigen 3 (PETA-3) or tetraspanin-24 (Tspan-24). Like other tetraspanin family members, CD151 contains four hydrophobic transmembrane domains, two short cytoplasmic tails, and one small and one large extracellular loop. CD151 is expressed by many different cell types such as platelets, immature hematopoietic cells, megakaryocytes, keratinocytes, epithelial cells, muscle cells, Schwann cells, vascular endothelium, as well as epithelial cells. It complexes with integrins and other transmembrane 4 superfamily proteins and is involved in cellular processes including cell adhesion and regulates integrin trafficking and function. CD151 enhances cell motility, invasion, and metastasis of tumor cells. | Additional information: Clone REA265 displays negligible binding to Fc receptors. | | |
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| Conjugate | Biotin | |
| Clone | REA265 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD151
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
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Validation References
| PMID 11774285 | |
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| PMID 15265795 | |
| PMID 24038174 | |
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