HLA DQ Monoclonal / APC / REA303

Product Details

Description	Clone REA303 recognizes HLA-DQ, an αβ heterodimer of the MHC class II type. Expressed on the surface of most nucleated cells, MHC class II molecules play an important role in the immune system. They are essential in the defense against infection and are a main consideration in transplantation medicine. In addition to presenting antigenic peptides from predominantly extracellular sources to CD4+ T cells, MHC class II molecules also mediate the thymic selection of T helper cells. MHC class II molecules consist of an α and β chain and are transported to endosomal-lysosomal compartments by the invariant chain. In humans, MHC class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display 70% similarity to each other. Both chains of HLA-DQ are polymorphic. Despite the essential function of MHC class II molecules in immune defense against pathogens, some alleles are frequently linked to immune diseases. Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and diabetes mellitus type 1. \| Additional information: Clone REA303 displays negligible binding to Fc receptor \|
Conjugate	APC
Clone	REA303
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

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