CD295 Monoclonal / APC / REA361
Product Details
| Description | Clone REA361 recognizes the human CD295 antigen, a single-pass type I membrane protein which is also known as leptin receptor (LEPR). CD295 is a member of the type I cytokine receptor family which acts through Janus kinases and signal transducers and activators of transcription. It is predominantly expressed in the central nervous system and in multiple tissues, including the choroid plexus, lung, kidney, and primitive hematopoietic cell populations. CD295 is the receptor for leptin, a peptide hormone which is secreted by the adipose tissue at levels roughly proportional to fat content. Leptin communicates the repletion of peripheral energy stores to the brain, suppressing feeding and permitting/promoting energy expenditure via a variety of neuroendocrine and autonomic mechanisms. | Additional information: Clone REA361 displays negligible binding to Fc receptors. | |
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| Conjugate | APC | |
| Clone | REA361 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD295
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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Validation References
| PMID 8548812 | |
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| PMID 8616721 | |
| PMID 19136996 | |
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