TLR6 Monoclonal / Biotin / REA382
Product Details
| Description | Clone REA382 recognizes the human CD286 antigen, a single-pass type I membrane protein also known as toll-like receptor 6 (TLR6). CD286 is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. Toll-like receptors are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various toll-like receptors exhibit different patterns of expression. CD286 is colocalized with TLR2 on the cell surface of monocytes/macrophages, dendritic cells, and granulocytes. It participates in the innate immune response to gram-positive bacteria and fungi and specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. CD286 acts via MYD88 and TRAF6, leading to NFkappaB activation, cytokine secretio,n and the inflammatory response. | Additional information: Clone REA382 displays negligible binding to Fc receptors. | | |
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| Conjugate | Biotin | |
| Clone | REA382 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About TLR6
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
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Validation References
| PMID 10231569 | |
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| PMID 16455646 | |
| PMID 22737174 | |
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