TIM-1 Monoclonal / APC-Vio770 / REA384
Product Details
| Description | Clone REA384 recognizes the human T cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a single-pass type I membrane protein also known as hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). TIM-1 is widely expressed, with highest levels in kidney and testis. It is also expressed by activated T cells, B cells, natural killer T cells, and dendritic cells. The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity in vivo through responses mediated by Tʜ1, Tʜ2, Tʜ17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. In addition to serving as a receptor for filoviruses, human TIM-1 is reported to serve as a receptor for hepatitis A virus and a variety of flaviviruses, alphaviruses, and arenaviruses. | Additional information: Clone REA384 displays negligible binding to Fc receptors. | |
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| Conjugate | APC-Vio770 | |
| Clone | REA384 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About TIM-1
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple other viruses, including Ebola virus, Marburg virus, Dengue virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and other coronaviruses. [provided by RefSeq, Sep 2021]
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple other viruses, including Ebola virus, Marburg virus, Dengue virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and other coronaviruses. [provided by RefSeq, Sep 2021]
About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.
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Validation References
| PMID 9658108 | |
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| PMID 23698310 | |
| PMID 24703780 | |
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