TIMP-3 Monoclonal / PE / REA417
Product Details
| Description | Clone REA417 recognizes the human tissue inhibitor of metalloproteinases 3 (TIMP-3) antigen, an extracellular matrix bound protein which is also known as MIG-5. TIMP-3 is expressed ubiquitously and is induced in response to mitogenic stimulation. It is a member of a family of endogenous matrix metalloproteinases inhibitors, of which there are currently four members (TIMP-1 through TIMP-4). By virtue of their matrix metalloproteinases inhibitory activity, TIMP family members have a potentially important function in regulating matrix composition and thereby affect a wide range of physiological processes including cell growth, invasion, migration, angiogenesis, transformation, and apoptosis. TIMP-3 complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Mutations in TIMP-3 are associated with Sorsby fundus dystrophy, a macular degenerative disease manifested by sudden loss of visual acuity in the third to fourth decades of life due to choroidal (submacular) neovascularization. | Additional information: Clone REA417 displays negligible binding to Fc receptors. | |
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| Conjugate | PE | |
| Clone | REA417 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About TIMP-3
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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Validation References
| PMID 8174111 | |
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| PMID 10818225 | |
| PMID 12652295 | |
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