FCRL1 Monoclonal / Biotin / REA440

Product Details

Description	Clone REA440 recognizes the human CD307a antigen, a single-pass type I membrane protein which is also known as Fc receptor-like protein 1 (FcRL1) or immune receptor translocation-associated protein 5 (IRTA5). CD307a is preferentially expressed on naive and memory B cells. It has two ITAM-like motifs, an acidic glutamic acid residue in its transmembrane region, and three extracellular immunoglobulin-like domains. Ligands for CD307a have not been identified, but the presence of ITAM-like motifs suggests its potential for B cell–activation. \| Additional information: Clone REA440 displays negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA440
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About FCRL1
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

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