TSPAN8 Monoclonal / VioBright FITC / REA443
Product Details
| Description | Clone REA443 recognizes the human tetraspanin-8 (TSPAN8) antigen, a multi-pass membrane protein which is also known as transmembrane 4 superfamily member 3 (TM4SF3) or tumor-associated antigen CO-029. TSPAN8 is a member of the transmembrane 4 superfamily, which is a group of cell surface glycoproteins that contain four transmembrane domains and two conserved extracellular loops. Tetraspanins interact and form complexes with a wide variety of proteins, including other members of the tetraspanin family, integrins, receptors, and signaling molecules. Through these interactions, they play important roles in fundamental cellular processes such as migration, proliferation, and differentiation. It is suggested that TSPAN8 is widely expressed in various tissues, including in the digestive tract, connective tissue, bone, muscle, and kidney. TSPAN8 has also been intensively studied in the field of cancer. It has been shown to be highly expressed in colorectal, hepatocellular, and pancreatic carcinoma cells along with integrin family proteins. Several studies have suggested that TSPAN8 is also involved in the migration and invasion of cancer cells. | Additional information: Clone REA443 displays negligible binding to Fc receptors. | |
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| Conjugate | VioBright FITC | |
| Clone | REA443 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About TSPAN8
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
About VioBright FITC
Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
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Validation References
| PMID 2395876 | |
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| PMID 20124479 | |
| PMID 24926311 | |
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