STAT1 (pY701) Monoclonal / PE / REA345

Product Details

Description	Clone REA345 recognizes the signal transducer and activator of transcription 1 (STAT1) antigen phosphorylated at tyrosine 701 (pY701). STAT1 expression is found ubiquitously. It is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to interferon gamma (IFN-gamma) stimulation, the STAT1 subunits become tyrosine-phosphorylated at pY701, and the complex is translocated to the nucleus. STAT1 forms homodimers or heterodimers with STAT3 that bind to the IFN-gamma activated sequence promoter element. In response to either IFN-alpha or IFN-beta stimulation, STAT1 forms a heterodimer with STAT2 that can bind the interferon stimulated response promoter element. In either case, binding of the promoter element leads to an increased expression of interferon stimulated genes. \| Additional information: Clone REA345 displays negligible binding to Fc receptors.
Conjugate	PE
Clone	REA345
Target Species	Human, Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.

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