CD278 Monoclonal / VioGreen / REA192

Product Details

Description	Clone REA192 recognizes CD278 (ICOS), which belongs to the CD28 family of proteins. CD28 family members are costimulatory receptor molecules, contain single immunoglobulin V-like domain, and belong to the immunoglobulin superfamily. CD287 recognizes inducible T cell costimulator ligand (ICOSL) as ligand and its expression is induced on activated T cells. Enhanced expression of CD278 is also observed on T cells, followed by costimulation of T cells via CD28. Further expression of CD278 is found on B cells, monocytes, and dendritic cells. Crosslinking of ICOS on T cell surface in the presence of primary stimulation signal leads to T cell proliferation and differentiation. In addition, CD278 plays role in Tʜ cell differentiation, effector T cell function, and isotype class switching. \| Additional information: Clone REA192 displays negligible binding to Fc receptors. \|
Conjugate	VioGreen
Clone	REA192
Target Species	Human, Mouse, Rat
Applications	FC
Supplier	Miltenyi Biotec
	Catalog #	Sign in to view product details, citations, and spectra
	Size
	Price
	Antigen
	Host
	Isotype

About CD278
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

About VioGreen
Vio®Green from Miltenyi has an excitation peak at 388 nm and an emission peak at 520 nm.

Experiment Design Tools