Dectin 1 Monoclonal / APC / REA154
Product Details
| Description | Clone REA154 recognizes murine dectin-1, which is approximately 40 kDa type II transmembrane protein, also known as mouse beta-glucan receptor or CLEC7A. It promotes the phagocytosis of intact yeasts and glucan particles such as beta-1,3-linked and beta-1,6-glucans, thus playing an important role in anti-fungal immunity. Neutrophils and macrophages express relatively higher levels of dectin-1 as compared to dendritic cells and subpopulation of T cells. In cooperation with TLR2 and TLR4, dectin-1 leads to cytokine production in human macrophages and monocytes. | Additional information: Clone REA154 displays negligible binding to Fc receptors. | | |
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| Conjugate | APC | |
| Clone | REA154 | |
| Target Species | Mouse | |
| Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About Dectin 1
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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Validation References
| PMID 10779524 | |
|---|---|
| PMID 12163569 | |
| PMID 12244185 | |
| PMID 18549457 | |
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299 Dectin 1 antibodies from over 21 suppliers available with over 33 conjugates.
