CD47 Monoclonal / Biotin / REA170

Product Details

Description	Clone REA170 recognizes CD47, which is also known as integrin-associated protein. CD47 is a 50 KDa heavily glycosylated protein with an extracellular IgV domain, five transmembrane domains and a cytoplasmic tail, which exists in 4 different isoforms. The expression of CD47 varies in different tissue types depending upon the cytoplasmic tail isoform associated, for e.g the 16 amino acid form 2, is expressed in all cells of hematopoietic origin, endothelial and epithelial cells whereas 36 amino acids form 4 is expressed mainly in neurons, intestine, and testis. CD47 can interact with integrins, Thrombospondin-1 (TSP-1), cell surface gylcoproteins SIRPalpha and SIRPbeta. Owing to these interactions, CD47 plays an important role in lymphocyte homeostasis, maturation and activation of dendritic cells, cellular transmigration and phagocytosis of cells. \| Additional Information: Clone REA170 displays negligible binding to Fc receptors. \|
Conjugate	Biotin
Clone	REA170
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About CD47
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

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