CD272 Monoclonal / PE / REA224
Product Details
| Description | Clone REA224 recognizes the mouse CD272 antigen, which is also known as B- and T-lymphocyte attenuator (BTLA) or B- and T-lymphocyte-associated protein. CD272, an Ig domain superfamily receptor protein with similarities to cytotoxic T-lymphocyte antigen-4 and programmed death-1, is expressed on various cell types like splenic T and B cells, macrophages, NK cells, dendritic cells as well as lymph node tissues but very weakly in somatic tissues. A polymorphic tissue distribution between several mouse strains is seen. Crosslinking CD272 with antigen receptors results in downregulation of T cell activation and attenuates production of interleukin 2. CD272 deficient mice have increased specific antibody responses and enhanced incidence and severity of autoimmune disorders. | Additional information: Clone REA224 displays negligible binding to Fc receptors. | | |
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| Conjugate | PE | |
| Clone | REA224 | |
| Target Species | Mouse | |
| Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD272
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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Validation References
| PMID 12796776 | |
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| PMID 20307212 | |
| PMID 23479601 | |
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