CD229 Monoclonal / APC-Vio770 / REA273

Product Details

Description	Clone REA273 recognizes both mouse CD229 antigen alleles, Ly9.1 and Ly9.2. CD229 is a glycoprotein of the SLAM family also known as Ly9 or SLAMF3 which is a homophilic cell surface receptor present on a variety of immune cell types including T cells, B cells, NK cells, and thymocytes. It has been shown to interact with the adaptor proteins, SLAM-associated protein and EAT-2. CD229 is highly expressed on innate-like lymphocytes such as iNKT cells and in contrast to SLAMF1 and SLAMF6, CD229 plays a negative rather than a positive role in the signaling pathways required for innate-like lymphocyte development in the thymus. \| Additional Information: Clone REA273 displays negligible binding to Fc receptors. \|
Conjugate	APC-Vio770
Clone	REA273
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About CD229
LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 [PubMed 16365421]).[supplied by OMIM, Mar 2008]

About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.

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