CCR6 Monoclonal / APC / REA277
Product Details
| Description | Clone REA277 recognizes the CD196 antigen, a G protein–linked chemokine receptor also known as C-C chemokine receptor type 6 (CCR6). CD196 is preferentially expressed by B cells, immature dendritic cells, and subsets of T cells. The ligand of CD196 is macrophage inflammatory protein 3 alpha (MIP-3alpha) and binding subsequently transduces a signal by increasing the intracellular calcium ions level. CD196 has been shown to be important for B-lineage maturation and antigen-driven B cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Targeting CD196 or its ligand may be a promising therapeutic strategy to alleviate atherosclerosis. | Additional information: Clone REA277 displays negligible binding to Fc receptors. | | |
|---|---|---|
| Conjugate | APC | |
| Clone | REA277 | |
| Target Species | Mouse | |
| Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
| Size | ||
| Price | ||
| Antigen | ||
| Host | ||
| Isotype |
About CCR6
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Experiment Design Tools
Panel Builders
Looking to design a Microscopy or Flow Cytometry experiment?
Validation References
| PMID 9169459 | |
|---|---|
| PMID 9294138 | |
| PMID 9862452 | |
| Additional Sources |
|
Reviews & Ratings
| Reviews |
|---|
Looking for more options?
656 CCR6 antibodies from over 27 suppliers available with over 83 conjugates.
