SHIP1 / HRP /

Product Details
Description SHIP, ID (INPP5D, SH2-containing Inositol 5-phosphatase 1, SH2 Domain-containing Inositol Phosphatase 1, SHIP-1, Inositol Polyphosphate-5-phosphatase of 145kD, SIP-145, p150Ship Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, hp51CN, SHIP1) (HRP) Pab
Conjugate HRP
Clone
Target Species Human
Applications ELISA, WB
Supplier US Biological
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About SHIP1
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]
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334 SHIP1 antibodies from over 24 suppliers available with over 44 conjugates.

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