CD68 Monoclonal / PE-Vio770 / REA237

Product Details
Description Clone REA237 recognizes rat CD68, also known as macrosialin, which is a heavily glycosylated type I transmembrane protein of the LAMP (lysosomal-associated membrane protein) family. CD68 is expressed by the majority of tissue macrophages and weakly by peripheral blood granulocytes. It is also present on rat Kupffer cells but absent from rat liver endothelial cells. The expression of rat CD68 is predominantly intracellular, but it is reported that weak cell surface expression also occurs as well. CD68 functions as a macrophage receptor for oxidized low density lipoprotein. | Additional information: Clone REA237 displays negligible binding to Fc receptors. |
Conjugate PE-Vio770
Clone REA237
Target Species Rat
Applications FC
Supplier Miltenyi Biotec
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About CD68
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
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Validation References
PMID 1919437
PMID 9065757
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