CD169 Monoclonal / APC-Vio770 / 7-239

Product Details

Description	The monoclonal antibody 7-239 reacts with CD169, also known as siglec-1 or sialoadhesin, which is a type I transmembrane glycoprotein. It is the largest member of the siglec family, which are cell surface lectins that are able to bind to sialic acids and mediate interactions between proteins and carbohydrates. Siglec-1 is mainly expressed on tissue macrophages and dendritic cells and interacts with its counterreceptor on T cells, which has been identified as CD43.
Conjugate	APC-Vio770
Clone	7-239
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About CD169
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.

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