CD273 Monoclonal / APC / MIH18

Product Details

Description	Clone MIH18 recognizes human CD273, also known as B7-DC and PD-L2. CD273 with an approximate molecular weight of 25 kDa is a type I transmembrane protein, belonging to the B7 family of protein ligands and to the Ig superfamily. CD273 is mainly expressed on dendritic cells (DCs) and activated macrophages. It has been shown to interact with programmed-death-receptor 1 (PD-1). Both a stimulatory and inhibitory role of CD273, in T cell activation has been proposed.
Conjugate	APC
Clone	MIH18
Target Species	Human
Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Supplier	Miltenyi Biotec
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About CD273
Involved in negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; and negative regulation of interleukin-10 production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of pulmonary tuberculosis. [provided by Alliance of Genome Resources, Apr 2022]

About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

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