CD41 Monoclonal / APC-Vio770 / MWReg30

Product Details

Description	Clone MWReg30 recognizes the mouse CD41 antigen, a single-pass type I membrane protein also known as integrin alpha2b or GPIIb. CD41 associates with CD61 to form the heterodimeric gpIIb/gpIIIa complex that is present on megakaryocytes, platelets, and early hematopoietic progenitors. The CD41/CD61 complex is a receptor for several adhesion molecules such as fibronectin, fibrinogen, plasminogen, and vitronectin and mediates platelets aggregation. CD41 expression marks the divergence of definitive hematopoietic precursors from the hemangioblasts or hemogenic endothelium during mouse embryonic development.
Conjugate	APC-Vio770
Clone	MWReg30
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About CD41
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]

About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.

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