CD134 Monoclonal / PE / OX-86

Product Details
Description The CD134 antigen, also known as OX40 receptor, is a 50 kDa type I membrane glycoprotein of the TNF/NGF receptor superfamily. It is expressed on activated mouse T cells and B cells. The OX40 receptor binds to the OX40 ligand (CD252) to provide a costimulatory signal which is independent of CD28. The OX-86 monoclonal antibody does not block this interaction and is reported to provide costimulation signals to T cells.
Conjugate PE
Clone OX-86
Target Species Mouse
Applications FC
Supplier Miltenyi Biotec
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About CD134
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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