LAT (pY226) Monoclonal / APC / REA146

Product Details

Description	Clone REA146 recognizes LAT phosphorylated at tyrosine 226. Linker of T cell activation (LAT), a transmembrane adaptor molecule, is constitutively localized in the lipid rafts and is involved in transducing the signal initiated by triggered T cell receptor (TCR). Upon TCR engagement, SRC and SYK family of protein tyrosine kinases (PTKs) are activated and LAT is phosphorylated at multiple conserved tyrosine residues in its cytosolic domain by Syk-family PTK Zap-70. Phosphorylated LAT can associate with several downstream SH2 domain containing proteins such as GRB2, PLCy1, ITK, GADS, and p85 subunit of PI3K to propagate the TCR activation signal and to activate several downstream pathways. pY226 motif can be bound directly by GRB2, GADS, and PLC-y1. Expression of LAT is found in thymocytes, T cells, mast cells, natural killer (NK cells), and platelets. Thymocytes lacking LAT are completely blocked at the pro-T3 stage in thymopoiesis. \| Additional information: Clone REA146 displays negligible binding to Fc receptors. \|
Conjugate	APC
Clone	REA146
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

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