CD38 Monoclonal / APC / 90.4

Product Details
Description Clone 90.4 reacts with CD38, a 42 kDa transmembrane glycoprotein. CD38 is expressed on B cells, NK cells and a subset of thymocytes and peripheral T cells. CD38 expression is downregulated on mouse germinal center B cells and mouse mature plasma cells. The CD38 molecule, a counter-receptor for CD31, is an ectoenzyme with cyclase and hydrolase enzymatic activity and plays a role in lymphocyte activation.
Conjugate APC
Clone 90.4
Target Species Mouse
Applications FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
Supplier Miltenyi Biotec
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About CD38
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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