Ly-6A/Ly-6E Monoclonal / Biotin / D7
Product Details
| Description | Sca-1 (stem cell antigen-1) is a 18 kDa GPI-linked surface protein of the Ly-6 family (Ly-6A/E). The Anti-Sca-1 antibody clone D7 specifically recognizes both Ly-6E.1 and Ly-6A.2, which are gene products of the two Ly-6A/E alleles expressed in different mouse strains (Ly-6E.1: e.g. BALB/c, C3H, NZB; Ly6A.2: e.g. C57BL/6, SJL, 129, AKR). | Sca-1 is expressed on hematopoietic stem cells and progenitor cells in mouse bone marrow and one of the defining markers for so-called KSL (c-kit+ Sca-1+ Lin-) cells. Sca-1 in combination with CD105 (Endoglin) expression has been used to define long-term repopulating hematopoietic stem cells (LTR-HSCs) in mouse bone marrow1,2. In addition, Sca-1+ bone marrow cells also contain the mesenchymal stem cell fraction present. Sca-1+ cells have been shown to give rise to hepatocytes in vivo 3) and neural cells in vitro. 4) Furthermore, Sca-1 is expressed on stem cells in a variety of nonhematopoietic tissues, such as adult liver 5), heart 6), and prostate. 7) | | |
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| Conjugate | Biotin | |
| Clone | D7 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About Ly-6A/Ly-6E
This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021]
This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021]
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Validation References
| PMID 10915564 | |
|---|---|
| PMID 11062533 | |
| PMID 12438646 | |
| PMID 12601361 | |
| PMID 14563317 | |
| PMID 14702342 | |
| PMID 15899981 | |
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