CD275 Monoclonal / Biotin / HK5.3
Product Details
| Description | Clone HK5.3 recognises murine CD275, which is also known as B7-H2 and ICOSL. CD275 is a type I membrane protein and belongs to the Ig superfamily, B7 family of costimulatory molecules. Expression of CD275 is found on antigen presenting cells such as B cells, dendritic cells, and monocytes. CD275 costimulates T cells upon binding to ICOS, which is expressed on activated T cells. In mouse, CD275 binds only ICOS, whereas in humans it can interact with other T cell costimulatory molecules, CD28 and CTLA-4. To appropriately regulate the activation of immune response, the ICOS-CD275 interaction can also lead to downregulation of CD275 expression which allows prevention of hyperreaction of T cells. | |
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| Conjugate | Biotin | |
| Clone | HK5.3 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD275
Enables identical protein binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-4 production. Located in cytoplasmic ribonucleoprotein granule and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Enables identical protein binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-4 production. Located in cytoplasmic ribonucleoprotein granule and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Validation References
| PMID 18390703 | |
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| PMID 21530327 | |
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