DCAR1 Monoclonal / Biotin / SKa5-3D5

Product Details

Description	Dendritic cell immunoactivating receptor 1 (DCAR1) belongs to a subfamily of cell surface C-type lectin receptors (CLR). Mouse DCAR1 shows a tissue specific expression pattern: it is expressed on CD8a+ DC subsets in spleen and thymus and on subsets of CD11b+ myeloid cells in bone marrow and spleen. Mouse DCAR1 has neither been detected in lymph nodes nor in peripheral blood. Antigen delivered via anti-DCAR1 antibody is internalized and is cycled through the early and late endosomal compartment, inducing cellular and humoral responses in vivo. Triggering DCAR1 via monoclonal antibody ligation on CD8+ DCs increases the secretion of bioactive IL-12 whereas secretion of IL-10 is markedly reduced, indicating that antigen recognized by mDCAR1 induces enhanced proinflammatory responses. Anti-DCAR1 antibodies have been tested on BALB/c and C57BL/6 mice.
Conjugate	Biotin
Clone	SKa5-3D5
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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