CD59a Monoclonal / PE-Vio770 / REA287

Product Details

Description	Clone REA287 recognizes the CD59a antigen, the murine analog of human CD59 which is also known as MAC-inhibitory protein (MAC-IP) or membrane attack complex inhibition factor (MACIF). CD59a is widely distributed, being present on all circulating cells, epithelia, and endothelia and in most tissues examined. CD59a blocks the formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex, hereby protecting the cells from complement-mediated lysis. Further, CD59a down-modulates CD4+ T cell activity in vitro and in vivo, thereby revealing another link between complement regulators and T cell activation. \| Additional information: Clone REA287 displays negligible binding to Fc receptors. \|
Conjugate	PE-Vio770
Clone	REA287
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.

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