IFNGR2 Monoclonal / Biotin / REA381

Product Details

Description	Clone REA381 recognizes the mouse IFN-gamma receptor beta chain antigen, a type 1 transmembrane protein also known as IFN-gamma accessory factor 1 (AF-1). The IFN-gammaR beta chain pairs with CD119 to form the IFN-gamma receptor. It is expressed at low levels on T and B cells, NK cells, monocytes, macrophages, and fibroblasts. IFN-gamma induces several biologic effects in target cells, including antiviral and antiproliferative responses, expression of major histocompatibility complex and of Fc receptor genes, and immunoglobulin class switching. \| Additional information: Clone REA381 displays negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA381
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About IFNGR2
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

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