CD103 Monoclonal / Biotin / Ber-ACT8
Product Details
| Description | Clone Ber-ACT 8 recognizes human CD103, a type I transmembrane protein, which is also known as alphaE integrin. It associates with integrin beta7 to form the heterodimeric integrin molecule alphaEbeta7 and is a receptor for the ligand E-cadherin expressed on epithelial cells. CD103 is found on intraepithelial and peripheral lymphocytes, such as regulatory T cell subpopulations. | |
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| Conjugate | Biotin | |
| Clone | Ber-ACT8 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD103
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
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Validation References
| PMID 1890196 | |
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| PMID 17137867 | |
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