DR3 Monoclonal / Biotin / JD3

Product Details

Description	Clone JD3 recognizes the human DR3 antigen, a member of the TNF-receptor superfamily which is also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25). DR3 is the receptor for TNFSF12 (APO3L, TWEAK) and interacts directly with the adapter TRADD. It mediates activation of NFkappaB and induces apoptosis. DR3 is expressed preferentially by activated and antigen-experienced T lymphocytes. It is also highly expressed by FoxP3-positive regulatory T lymphocytes. DR3 is activated by TNFSF15, which is rapidly upregulated in antigen-presenting cells and some endothelial cells following toll-like receptor or Fc receptor activation. Multiple alternatively spliced transcript variants of this gene-encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of DR3 in B and T cells encounters a programmed change upon T cell–activation, which predominantly produces full-length, membrane-bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T cell–activation. DR3 stimulation is therefore highly specific to T cell–mediated immunity, which can be used to enhance or dampen inflammation depending on the temporal context and quality of foreign versus self antigen availability. Stimulation of DR3 in humans leads to similar effects as costimulatory blockade targeting molecules such as CTLA-4 and PD-1.
Conjugate	Biotin
Clone	JD3
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About DR3
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

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