CD18 Monoclonal / Biotin / TS1/18

Product Details

Description	Clone TS1/18 reacts with CD18, a type I transmembrane protein with an approximate molecular weight of 90–95 kDa. It non-covalently associates with alpha subunits CD11a (alphaL), CD11b (alphaM), CD11c (alphaX), and CD11d (alphaD) to form functional integrins which are expressed on leucocytes. CD18 associated integrins bind several ligands including cell surface and extracellular matrix proteins and are involved in cell-cell and cell-extracellular matrix interactions, immune regulation, and immune tolerance. Leucocytes of patients lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.
Conjugate	Biotin
Clone	TS1/18
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About CD18
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

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