IFN-alpha/beta R2 Monoclonal / PE-Vio770 / REA124
Product Details
| Description | Clone REA124 recognizes the human interferon alpha/beta receptor 2 (IFNAR2) antigen, a 100 kDa single-pass type I membrane protein that forms one of the two chains of a receptor for the type I interferons IFN-alpha, IFN-beta, and IFN-ω. These interferons are a group of structurally and functionally related proteins, induced by viruses or double-stranded RNA and defined by their ability to establish an antiviral state in cells. IFNAR2 is expressed on most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression is higher on monocytes and granulocytes than on lymphocytes. It is involved in IFN-mediated STAT1, STAT2, and STAT3 activation. The alternatively spliced isoform of IFNAR2 is a potent inhibitor of type I IFN receptor activity. | Additional information: Clone REA124 displays negligible binding to Fc receptors. | |
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| Conjugate | PE-Vio770 | |
| Clone | REA124 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About IFN-alpha/beta R2
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]
About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
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Validation References
| PMID 7479825 | |
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| PMID 7759950 | |
| PMID 8181059 | |
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