CD3 epsilon Monoclonal / PE-Vio770 / 17A2

Product Details
Description The monoclonal antibody 17A2 reacts with mouse CD3ε, a part of the CD3 complex and a subunit of the TCR complex, which is expressed on all mature T lymphocytes, NKT cells, and during the development of thymocytes. Binding of 17A2 antibody to CD3 induces cell activation and proliferation.
Conjugate PE-Vio770
Clone 17A2
Target Species Mouse
Applications FC
Supplier Miltenyi Biotec
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About CD3 epsilon
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
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Validation References
PMID 1686832
PMID 2534389
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