CD8b / ECD / 2ST8.5H7
Product Details
| Description | CD8beta Human (2ST8.5H7); IOTest ; ECD ; 100 tests ; Liquid ; RUO | |
|---|---|---|
| Conjugate | ECD | |
| Clone | 2ST8.5H7 | |
| Target Species | Human | |
| Applications | ||
| Supplier | Beckman Coulter | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD8b
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
About ECD
ECD is a tandem fluorophore designed for flow cytometry, spectrally similar to PE-CF®594, PE-Texas Red, PE-Dazzle 594 and PE-eFluor™ 610.
ECD is a tandem fluorophore designed for flow cytometry, spectrally similar to PE-CF®594, PE-Texas Red, PE-Dazzle 594 and PE-eFluor™ 610.
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