DC-SIGN / Brilliant Blue 515 / DCN46

Product Details
Description BB515 Mouse Anti-Human CD209
Conjugate Brilliant Blue 515
Clone DCN46
Target Species Human
Applications FC
Supplier BD Biosciences
Catalog # Sign in to view product details, citations, and spectra
Size
Price
Antigen
Host
Isotype
About DC-SIGN
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020]
About Brilliant Blue 515
Horizon Brilliantâ„¢ Blue 515 (BB515), exclusive to BD Biosciences, is a brighter alternative to FITC and Alexa Fluorâ„¢ 488 in flow cytometry. It has an excitation peak at 590 nm and an emission peak at 515 nm.
Experiment Design Tools
Panel Builders

Looking to design a Microscopy or Flow Cytometry experiment?

Validation References
Additional
Sources
Reviews & Ratings
Looking for more options?

293 DC-SIGN antibodies from over 22 suppliers available with over 47 conjugates.

Supplier Page
 Compare