TNF alpha / Unconjugated / SPM543

Product Details
Description Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Conjugate Unconjugated
Clone SPM543
Target Species Human
Applications IF, IHC-P
Supplier NSJ Bioreagents
Catalog # Sign in to view product details, citations, and spectra
Size
Price
Antigen
Host
Isotype
Experiment Design Tools
Conjugation Options

Pair this antibody with compatibility secondary antibodies, and conjugation kits and services:

Panel Builders

Looking to design a Microscopy or Flow Cytometry experiment?

Validation References
Additional
Sources
Reviews & Ratings
Looking for more options?

2470 TNF alpha antibodies from over 43 suppliers available with over 83 conjugates.

Supplier Page
 Compare