IL-4 / PromoFluor 488P / IL4-3

Product Details
Description anti-human IL-4 mAb IL4-3, PF488P
Conjugate PromoFluor 488P
Clone IL4-3
Target Species Human, Non-Human Primate
Applications FC
Supplier Mabtech
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About IL-4
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
About PromoFluor 488P
PromoFluor 488P is a fluorophore with an excitation peak at 490 nm and an emission peak at 516 nm. It is equivalent to Alexa Fluorâ„¢ 488 and DyLightâ„¢ 488 in size, brightness and application. It can be used with the following analysis platforms: Flow Cytometry and Fluorescence Microscopy.
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