TSC2 / Unconjugated /

Product Details

Description	Rabbit polyclonal to TSC2.Tuberin (TSC2) forms a complex with TSC1 and inhibits the nutrient-mediated or growth factorstimulatedphosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling.TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of theprotein kinase activity of mTORC1. It is implicated as a tumor suppressor. TSC2 is involved inmicrotubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Defects in TSC2 causetuberous sclerosis type 2 (TSC2) and lymphangioleiomyomatosis (LAM). -
Conjugate	Unconjugated
Clone
Target Species	Human, Mouse
Applications	WB
Supplier	Biorbyt
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About TSC2
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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