Spectrin beta 3 / Unconjugated / SPTBN2/1583

Product Details
Description Mouse monoclonal antibody to SPTBN2
Conjugate Unconjugated
Clone SPTBN2/1583
Target Species Human
Applications FC, IF, IHC-P, ICC, WB
Supplier Biorbyt
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About Spectrin beta 3
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
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