SENP5 / Unconjugated /
Product Details
| Description | Rabbit polyclonal to SENP5.Sentrin-specific protease 5 (SENP5) is a protease that belongs to the peptidase C48 family. SENP5catalyzes two essential functions in the SUMO pathway: processing full-length SUMO3 to its matureform and deconjugation of SUMO2 and SUMO3 from targeted proteins. It has weak proteolytic activityagainst full-length SUMO1 or SUMO1 conjugates. SENP5 is required for cell division. | |
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| Conjugate | Unconjugated | |
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| Target Species | Human | |
| Applications | WB | |
| Supplier | Biorbyt | |
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About SENP5
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
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