PRDM16 / Unconjugated /

Product Details

Description	Rabbit polyclonal to PRDM16.PR domain containing 16 (PRDM16) is a zinc finger transcription factor that binds to DNA andfunctions as a transcriptional regulator. It functions in the differentiation of brown adipose tissuewhich is specialized in dissipating chemical energy in the form of heat in response to cold or excessfeeding while white adipose tissue is specialized in storage of excess energy and the control ofsystemic metabolism. PRDM16 along with CEBPB regulate the differentiation of myoblasticprecursors into brown adipose cells. This gene has been implicated in a translocation event thatoccurs in a subset of acute myeloid leukemia and myelodysplastic syndrome. -
Conjugate	Unconjugated
Clone
Target Species	Mouse
Applications	WB
Supplier	Biorbyt
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About PRDM16
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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