PGC-1 alpha / Unconjugated /
Product Details
| Description | Rabbit polyclonal to PPARGC1A. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A ) is a transcriptional coactivator for steroid receptors and nuclear receptors. PPARGC1A greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Also, PPARGC1A can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. PPARGC1A plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. | |
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| Conjugate | Unconjugated | |
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| Target Species | Human | |
| Applications | WB | |
| Supplier | Biorbyt | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About PGC-1 alpha
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
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288 PGC-1 alpha antibodies from over 17 suppliers available with over 40 conjugates.
