PGC-1 alpha / Biotin /

Product Details

Description	PGC1 alpha also known as PPARGC1A (PPARG Coactivator 1 Alpha) it is a Protein Coding gene. Diseases associated with PPARGC1A include Obesity and Lipomatosis. Among its related pathways are Signaling mediated by p38-alpha and p38-beta and Circadian rythm related genes. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PPRC1. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. -
Conjugate	Biotin
Clone
Target Species	Human, Mouse, Rat
Applications	IF, ICC
Supplier	Biorbyt
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About PGC-1 alpha
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

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