Mortalin / Alk Phosphatase / S52A-42

Product Details

Description	Mouse monoclonal to Grp75 (Alkaline Phosphatase). Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat inducible. Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle. Related forms may also be found in the cytosol or on the surface of the extracellular membrane. Other Grp75 functions include its ability to inactivate the tumor suppressor p53. Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation. Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts. And finally, like its E. coli homolog DnaK, GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone (9, 10)..
Conjugate	Alk Phosphatase
Clone	S52A-42
Target Species	Human, Rat
Applications	IHC-P, WB, IP
Supplier	Biorbyt
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About Mortalin
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

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