EHMT1 / Unconjugated /
Product Details
| Description | Rabbit polyclonal to EHMT1.EHMT1 is a Histone-lysine N-methyltransferase that specifically mono-and dimethylates 'Lys-9' ofhistone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tagfor epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1also weakly methylates 'Lys-27' of histone H3 (H3K27me). EHMTa is also required for DNAmethylation independent of its histone methyltransferase. During G0 phase, EHMT1 contributes tosilencing of MYC-and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. Inaddition to the histone methyltransferase activity, EHMT1 also methylates non-histone proteins, suchas the dimethylation of 'Lys-373' of p53/TP53. | |
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| Conjugate | Unconjugated | |
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| Target Species | Human | |
| Applications | WB | |
| Supplier | Biorbyt | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About EHMT1
The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
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