E4F1 / Unconjugated /
Product Details
| Description | Rabbit polyclonal to E4F1.Transcription factor E4F1 may function as a transcriptional repressor. It may also function as aubiquitin ligase mediating ubiquitination of chromatin-associated TP53. E4F1 functions in cell survivaland proliferation through the control of the cell cycle. It functions in the p53 and pRB tumorsuppressor pathways and regulates the cyclin CCNA2 transcription. It is identified as a cellular targetof the adenoviral oncoprotein E1A, and it is required for both transcriptional activation and repressionof viral genes. | |
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| Conjugate | Unconjugated | |
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| Target Species | Human | |
| Applications | WB | |
| Supplier | Biorbyt | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About E4F1
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]
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89 E4F1 antibodies from over 7 suppliers available with over 31 conjugates.
