CD8 / CF594 /

Product Details

Description	Rabbit polyclonal to CD8, was first discovered as a cell surface marker in mice and was used to distinguish between CD8+ CTLs and CD4+ Th cells. CD8 exists as both a heterodimer (CD8??) and a homodimer (CD8??) of which the former is expressed on the majority of CTLs. CD8 has been shown to be involved in CTL co-activation by increasing antigen sensitivity, and by stabilizing the TCR/pMHC interaction. In order to carry out these roles, the CD8 co-receptor binds to a distinct invariant region of the pMHCI molecule, compared to the TCR, allowing the potential for tripartite (TCR/pMHC/CD8) complex formation. CD8 is most often described as a T-cell co-receptor because it plays an important role in T-cell signaling, via p56lck, to induce TCR mediated T-cell activation signals. Work in our lab and others has shown that the CD8 co-receptor is also important for CD8+ T-cell development, stabilization of the interface between CD8+ T-cells and target cells, and activation of intestinal epithelial T lymphocytes (iIELs). -
Conjugate	CF594
Clone
Target Species	Human, Mouse
Applications	IF, ICC
Supplier	Biorbyt
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About CF594
CF®594 from Biotium is a fluorophore with an excitation peak at 593 nm and an emission peak at 614 nm. It can be useful in both fluorescence microscopy and flow cytometry. It is spectrally similar to Alexa Fluor™ 594, DyLight™ 594 and Texas Red. However, in flow cytometry, PE-CF®594 and PE-Dazzle 594 are superior alternatives. In microscopy, CF®594 has been validated in STED and 2-Photon microscopy.

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