BLNK (pY84) / Unconjugated / BLNKY84-H4

Product Details
Description Phospho-BLNK (Tyr84) Recombinant Rabbit Monoclonal Antibody (BLNKY84-H4)
Conjugate Unconjugated
Clone BLNKY84-H4
Target Species Human
Applications FC
Supplier Thermo Fisher Scientific
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About BLNK (pY84)
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
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