CD82 / Biotin / REA221

Product Details

Description	Clone REA221 recognizes CD82, a member of the four transmembrane domain, tetraspanin family. Tetraspanins contain short, cytoplasmic amino and carboxyl termini and two extracellular loops of unequal sizes and can be distinguished from other membrane proteins, with same topology, due to conserved residues within the transmembrane domains and in the larger extracellular loops. CD82 interacts with other tretaspanins and membrane proteins, thus regulating several functions such as signal transduction. On the surface of tumor cells, CD82 interacts with integrins and is suggested to serve as a supressor of tumor metastasis. In addition, on immune cells such as T cells, CD82 associates with CD81, CD4, or CD8 and class II major histocompatibility complex (MHC), components of the antigen-processing and presentation pathway and tetraspanin CD63, in dendritic cells. Expression of CD82 is found on dendritic cells, monocytes, granulocytes, lymphocytes, epithelial, and endothelial cells. \| Additional information: Clone REA221 displays negligible binding to Fc receptors. \|
Conjugate	Biotin
Clone	REA221
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
	Catalog #	Sign in to view product details, citations, and spectra
	Size
	Price
	Antigen
	Host
	Isotype

About CD82
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Experiment Design Tools